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Below, you’ll find my writing organized by publication type. For questions on any specific publication, feel free to message my email, and I will respond as soon as possible. In addition, my commitment to academic excellence has been recognized through various grants and funds.
Below, you’ll find my writing organized by publication type. For questions on any specific publication, feel free to message my email, and I will respond as soon as possible. In addition, my commitment to academic excellence has been recognized through various grants and funds.
Selected Publications
Selected Publications
Abdalrahman Khalifa, Manal M. Anwar, Walaa A. Alshareef, Eman Abd Elaziz El Gebaly, Samia A. Elseginy, and Sameh Abdelwahed. Design, Synthesis, and Antimicrobial Evaluation of Some New Thiopyrimidin-Benzenesulfonamide Compounds. Molecules 2024, 29, 4778. https://doi.org/10.3390/molecules29194778
Somaia S. Abd El-Karima, Manal M. Anwara, Yasmin M. Syama, Hassan M. Awad, Asmaa Negm El-Dein, Mohamed K. El-Ashrey, and Sameh Abdelwahed. New Benzofuran-Pyrazole Based Compounds as Promising Antimicrobial Agents: Design, Synthesis, Antioxidant, Anti-inflammatory, DNA Gyrase B Inhibition and In Silico Studies. Pharmaceuticals 2024, 17, 1664. https://doi.org/10.3390/ph17121664
Ahmad Junaid, Joel Caleb Nwaogwugwu, and Sameh Abdelwahed. Exploring the Role of TRANSKETOLASE LIKE-1 (TKTL-1) in Cancer: Insights into Oncogenic Metabolism and Therapeutic Prospects. Cancer Informatics. Accepted and under publication, 2024.
Vishav Sharma, Dmytro Fedoseyenko, Sumedh Joshi, Sameh Abdelwahed, and Tadhg P. Begley. Phosphomethylpyrimidine Synthase (ThiC): Trapping of Five Intermediates Provides Mechanistic Insights on a Complex Radical Cascade Reaction in Thiamin Biosynthesis; ACS Central Science 2024 10 (5), 988-1000 DOI: 10.1021/acscentsci.4c00125.
Abdel-Mohsen, Heba T., Manal M. Anwar, Nesreen S. Ahmed, Somaia S. Abd El-Karim, and Sameh H. Abdelwahed. 2024. "Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present)" Molecules 2024, 29, 875. https://doi.org/10.3390/molecules29040875
Rajendra Rathore, Sameh H. Abdelwahed; Design and Synthesis of Cofacially-Arrayed Polyfluorene Wires for Electron and Energy Transfer Studies; Molecules 2023 28 (9), 3717; https://doi.org/10.3390/molecules28093717
Rajendra Rathore, Sergey V. Lindeman Sameh H. Abdelwahed; Design, Synthesis, Electronic Properties, and X-ray Structural Characterization of Various Modified Electron-Rich Calixarene Derivatives and Their Conversion to Stable Cation Radical Salts; Molecules 2022, 27(18), 5994; https://doi.org/10.3390/molecules27185994
Yasmin M. Syam, Manal M. Anwar, Somaia S. Abd El-Karim ,Khaled M. Elokelyand, Sameh H. Abdelwahed; New Quinoxaline-Based Derivatives as PARP-1 Inhibitors; Design, Synthesis, Antiproliferative, and Computational Studies; Molecules 2022, 27(15), 4924; https://doi.org/10.3390/molecules27154924
Ahmad Junaid, Grace Abolaji, Sameh Abdelwahed. Computational Screening for Novel Herbal-based SARSCoV-2 Structural Protein Modulators. Biomed J Sci & Tech Res 40(1)-2021. BJSTR. MS.ID.006400
Zhang, X.; Basuli, F.; Abdelwahed, S.; Begley, T.; Swenson, R., Radiosynthesis of 5-[18F] Fluoro-1,2,3-triazoles through Aqueous Iodine–[18F]Fluorine Exchange Reaction. Molecules 2021, 26 (18), 5522.
Charge-transfer or excimeric state? Exploring the nature of the excited state in cofacially arrayed polyfluorene derivatives A Abzhanova, LV Ivanova, D Wang, TS Navale, SH Abdelwahed, Journal of Photochemistry and Photobiology A: Chemistry 2019, 374, 125-130
Derek M. Gagnon, Troy A. Stich, Angad P. Mehta, Sameh H. Abdelwahed, Tadhg P. Begley, R. David Britt, An Aminoimidazole Radical Intermediate in the Anaerobic Biosynthesis of the 5,6-dimethylbenzimidazole Ligand to Vitamin B12. Journal of the American Chemical Society., 2018, 140 (40), pp 12798–12807.
Maxim V. Ivanov, Marat R. Talipov, Anitha Boddeda, Sameh H. Abdelwahed, and Rajendra Rathore; ‘Hückel Theory + Reorganization Energy = Marcus−Hush Theory: Breakdown of the 1/n Trend in π-Conjugated Poly-p-phenylene Cation Radicals Is Explained’ Journal of Physical Chemistry C (2017), 121(3), 1552-1561.
Isita Jhulki, Prem K. Chanani, Sameh H. Abdelwahed, and Tadhg P. Begley; ”Roseoflavin biosynthesis: A remarkable oxidative cascade that replaces the riboflavin C8 methyl with an amino group”; Journal of the American Chemical Society, (2016), 138 (27), pp 8324–8327.
Marat R. Talipov, Sameh H. Abdelwahed, Khushabu Thakur, Scott A. Reid, and Rajendra Rathore; “From Wires to Cables: Attempted Synthesis of 1,3,5-Trifluorenylcyclohexane as a Platform for Molecular Cables” Journal of Organic Chemistry (2016), 81(4), 1627-1634.
Angad P. Mehta, Sameh H. Abdelwahed, Michael K. Fenwick, Amrita B. Hazra, Michiko E. Taga, Yang Zhang, Steven E. Ealick, and Tadhg P. Begley; ‘Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B12 Biosynthesis’; Journal of the American Chemical Society (2015), 137(33), 10444-10447.
Michael K. Fenwick , Angad P. Mehta, Yang Zhang, Sameh H. Abdelwahed, Tadhg P. Begley and Steven E. Ealick; ‘Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase’; Nature communications (2015), 66480.
Angad P. Mehta, Sameh H. Abdelwahed, Tadhg P. Begley; ‘Molybdopterin biosynthesis - Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP’: Biochimica et Biophysica Acta, Proteins and Proteomics (2015).
Angad P. Mehta, Sameh H. Abdelwahed, Nilkamal Mahanta, Dmytro Fedoseyenko, Benjamin Philmus, Lisa E. Cooper, Yiquan Liu, Isita Jhulki, Steven E. Ealick, and Tadhg P. Begley; ‘Radical S-Adenosylmethionine (SAM) Enzymes in Cofactor Biosynthesis: A Treasure Trove of Complex Organic Radical Rearrangement Reactions”; Journal of Biological Chemistry (2015), 290(7), 3980- 3986.
Angad P. Mehta, Sameh H. Abdelwahed, Hui Xu, and Tadhg P. Begley “Molybdopterin Biosynthesis: Trapping of Intermediates for the MoaA-Catalyzed Reaction Using 2′-DeoxyGTP and 2′-ChloroGTP as Substrate Analogues. Journal of the American Chemical Society, (2014), 136 (30), pp 10609–10614.
Angad P Mehta, Sameh H Abdelwahed, and Tadhg P. Begley “Molybdopterin biosynthesis: Trapping an unusual purine ribose adduct in the MoaA-catalyzed reaction” Journal of the American Chemical Society, (2013), 135 (30), 10883–10885.
Lisa E. Cooper, Dmytro Fedoseyenko, Sameh H. Abdelwahed, Soong-Hyun Kim, Tohru Dairi , Tadhg P. Begley “In vitro reconstitution of the radical SAM enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinone” Biochemistry, (2013), 52 (27), 4592–4594.
Angad P Mehta, Jeremiah W. Hanes, Sameh H Abdelwahed, David George Hilmey, Petra Hänzelmann, and Tadhg P. Begley. Biochemistry (2013), 52(7) 1134–1136.
Honglan Qi, Jinho Chang, Sameh H. Abdelwahed, Khushabu Thakur, Rajendra Rathore, and Allen J. Bard; Journal of the American Chemical Society (2012), 134 (39),16265–16274.
Philmus, Benjamin; Sameh H. Abdelwahed; Williams, Howard J.; Fenwick, Michael K.; Ealick, Steven E.; Begley, Tadhg P.”Identification of the Product of Toxoflavin Lyase: Degradation via a Baeyer-Villiger Oxidation” Journal of the American Chemical Society (2012), 134(11), 5326-5330.
Josh Vura-Weis, Sameh H. Abdelwahed, Ruchi Shukla, Rajendra Rathore, Mark A. Ratner, Michael R. Wasielewski “Crossover from Single-Step Tunneling to Multistep Hopping for Molecular Triplet Energy Transfer”. Science (2010), 328(5985), 1547-1550.
Abhishek Chatterjee, Amrita B. Hazra, Sameh H. Abdelwahed, David G. Hilmey and Tadhg P. Begley. "A radical dance in thiamin biosynthesis:mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase " Angewandte Chemie, International Edition (2010), 49(46), 8653-8656.
Mukherjee, Tathagata; Zhang, Yang; Abdelwahed, Sameh; Ealick, Steven; Begley, Tadhg. “Catalysis of a novel flavoenzymemediated amide hydrolysis” Journal of the American Chemical Society (2010), 132(16), 5550-5551.
Rajendra Rathore, Sameh H. Abdelwahed, Mathew K. Kiesewetter, Richard C. Reiter and Cheryl D. Stevenson. “Intramolecular Electron Transfer Tunneling in -stacked polyfluorenes”. Journal of Physical Chemistry B (2006), 110(4), 1536-1540.
Cheryl D. Stevenson, Mathew K. Kiesewetter, Richard C. Reiter, Sameh H. Abdelwahed and Rajendra Rathore. “Intramolecular CH/C-D Exchange in Cofacially Stacked Polyfluorenes via Electron Induced Bond Activation”. Journal of the American Chemical Society (2005), 127(15), 5282-5283.
Rajendra Rathore, Vincent J. Chebny and Sameh H. Abdelwahed “A Varsatile and Conformationally-Adaptable Fluorene-Based Receptore for Efficiebt Binding of Silver Cation”. Journal of the American Chemical Society (2005), 127(22), 8012-8013.
Rajendra Rathore, Sameh A. Abdelwahed. “Soluble cycloannulated tetroxa [8]circulane derivatives: synthesis, optical and electrochemical properties, and generation of their robust cation–radical salts” Tetrahedron Letters (2004), 45(27), 5267-5270.
Rajendra Rathore, Carrie L. Burns, and Sameh H. Abdelwahed. “Hopping of a Single Hole in hexakis[4-(1,1,2-Triphenylethenyl)phenyl]benzene Cation Radical through the Hexaphenylbenzene Propeller”. Organic Letters (2004), 6(11), 1689-1692.
Rajendra Rathore, Sameh H. Abdelwahed, and Ilia A. Guzei. “Synthesis of a Calix[4]arene Derivative for Isolation of a Stable Cation Radical Salt for Use as a Colorimetric Sensor of Nitric Oxide”. Journal of the American Chemical Society (2004), 126(42), 13582- 13583.
Rajendra Rathore, Sameh H. Abdelwahed, and Ilia A. Guzei. “Synthesis, Structure, and Evaluation of the Effect of Multiple Stacking on the Electron-Donor Properties of -Stacked Polyfluorenes”. Journal of the American Chemical Society (2003), 125(29), 8712- 8713.
H. H. Fahmy ; S. H. A. Abdelwahed; A. A. Hamdy. “Synthesis of some new heterocyclic compounds containing benzimidazole moiety as potential antimicrobial agents", Egyptian Journal of Chemistry. (2003), 46 (2), 313-327.
Fahmy H.H, El-masry A, Ali Abdelwahed S. H. “Synthesis and preliminary antimicrobial screening of new benzimidazole heterocycles”. Archives of Pharmacal Research. (2001), 24(1), 27-34.
Afaf H. El-masry, H. H. Fahmy and S. H. Ali Abdelwahed. “Synthesis and Antimicrobial Activity of Some New Benzimidazole Derivatives” Molecules (2000) 5, 1429-1438.
Selected Professional Presentations
Selected Professional Presentations
Southwest Regional Meeting of the American Chemical Society
Title: "Exploring New Inhibitors for SARS-CoV-2 Main Protease"
Date: November 15-18, 2023
Location: Oklahoma City, OK
11th Young Researcher Conference
Title: "The Multifaceted Applications of Chemistry: Exploring its Role in Medicinal, Electrical, and Enzymatic Pathways"
Date: May 17-19, 2023
Location: Texas A&M University
The 9th Texas Enzyme Mechanisms Conference
Title: "Exploring New Inhibitors for SARS-CoV-2 Main Protease"
Date: June 3, 2023
Location: The University of Texas, Austin
28th Congress of the International Society of Heterocyclic Chemistry
Title: "New quinoxaline-based derivatives as PARP-1 inhibitors: design, synthesis, antiproliferative, and computational studies"
Date: August 28 to September 2, 2022
Location: UCSB California
8th Texas Enzyme Mechanisms Conference
Title: "Homology Modeling of Transketolase Like-1 (TKTL-1) Enzyme: A Pathway for Structure-based Drug Design for TKTL-1 Modulators"
Date: January 3rd and 4th, 2020
Location: The University of Texas Austin
American Chemical Society, 253rd National Meeting
Title: "Thiamine as a carrier for drug delivery to cancer cells"
Date: April 2-6, 2017
Location: San Francisco, California
American Chemical Society, 249th National Meeting
Title: "How nature makes vitamin B12; The last unsolved biosynthetic module"
Date: March 22-26, 2015
Location: Denver, Colorado
American Chemical Society, 247th National Meeting
Title: "Identification and characterization of new protein thiocarboxylate in bacteria"
Date: March 16-20, 2014
Location: Dallas, Texas
American Chemical Society, 246th National Meeting
Title: "Biosynthesis of dimethylbenzimidazole: Catalysis of a remarkable flavin degradation reaction"
Date: September 8-12, 2013
Location: Indianapolis, Indiana
Texas Enzyme Mechanisms Conference
Date: January 6 & 7, 2012
Location: The University of Texas at Austin
American Chemical Society Milwaukee Section Meeting
Title: "Synthesis of a Calix[4]arene Derivative for Isolation of a Stable Cation Radical Salt for Use as a Colorimetric Sensor of Nitric Oxide"
Date: April 11, 2005
Location: Milwaukee, WI
American Chemical Society, 229th National Meeting
Title: "Studies of Intramolecular Energy Transfer through Cofacially -Stacked Polyfluorene Spacers"
Date: March 13-17, 2005
Location: San Diego, CA
Grants
Grants
FY 2023 Panther Research and Innovation for Scholarly Excellence (PRISE) grant program, Earned $40,000
FY 2022 The Department of Defense-Historically Black Colleges and Universities (DoD-HBCU) Equipment Award, Earned $112,187
FY 2019 Faculty Research Development Grant Program (FRDGP), Earned $90,000.
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