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With over 34 peer-reviewed publications in top-tier journals such as Science, Nature Communications, Journal of the American Chemical Society, Organic Letters, Biochemistry, and Angewandte Chemie International Edition, Dr. Abdelwahed has made significant contributions to the scientific community. His work, which has garnered over 1,500 citations, primarily focuses on understanding complex chemical processes and applying this knowledge to develop innovative solutions in medicinal chemistry. He aims to bridge the gap between fundamental research and practical applications, contributing to advancements in health, energy, and technology.
With over 34 peer-reviewed publications in top-tier journals such as Science, Nature Communications, Journal of the American Chemical Society, Organic Letters, Biochemistry, and Angewandte Chemie International Edition, Dr. Abdelwahed has made significant contributions to the scientific community. His work, which has garnered over 1,500 citations, primarily focuses on understanding complex chemical processes and applying this knowledge to develop innovative solutions in medicinal chemistry. He aims to bridge the gap between fundamental research and practical applications, contributing to advancements in health, energy, and technology.
Research Interests
Research Interests
Medicinal Chemistry:
Cancer Therapy,
Antiviral Treatments, and
Radiopharmaceuticals.
Design and Synthesis of Bioactive Organic Compounds.
Design and Synthesis of Novel Electro-Active Molecules.
Complex Chemical Processes: Enzyme-Catalyzed Reactions.
Electronic Materials.
Research Topics
Research Topics
1. Antiviral Drug Development
1. Antiviral Drug Development
Exploring medicinal plants for antiviral properties, particularly against SARS-CoV-2. This involves computational virtual screening to identify potential herbal-based modulators for developing novel antiviral treatments.
Recent Publications:
2. Cancer Therapy and Drug Development
2. Cancer Therapy and Drug Development
Developing targeted anticancer therapies by designing and optimizing quinazoline-based and quinoxaline-based compounds. This includes focusing on protein kinase inhibitors and PARP-1 inhibitors to create safer, more effective treatments with high selectivity and low toxicity.
Recent Publications:
3. Electronic Materials and Energy Transfer
3. Electronic Materials and Energy Transfer
Advancing the design of materials with optimized optoelectronic properties for electronic and energy applications. This includes studying cofacially arrayed π-systems like polyfluorenes and calixarene derivatives to improve charge and energy transfer in semiconductors, with applications in photovoltaics and other electronic devices.
Recent Publications:
4. Radiopharmaceuticals and PET Imaging
4. Radiopharmaceuticals and PET Imaging
Developing new methods for radiolabeling compounds, particularly for PET imaging. This includes optimizing the radiosynthesis process for triazoles, aiming to create more efficient and functional PET imaging agents.
Recent Publications:
Research Collaborations with Texas A&M University
Research Collaborations with Texas A&M University
Enzyme Catalysis and Radical Intermediates
Enzyme Catalysis and Radical Intermediates
Position: Visiting Scholar.
Location: Department of Chemistry.
Collaborator: Distinguished Professor Tadgh Begley.
Research Focus:
Investigating the mechanisms of enzyme-catalyzed reactions, particularly those involving radical intermediates.
Understanding their role in essential biosynthetic pathways like thiamin and vitamin B12 production.
Exploring the evolutionary significance and impact on enzyme function in metabolic regulation.
Recent Publications:
Novel inhibitors for the SARS-CoV-2 and Cancer.
Novel inhibitors for the SARS-CoV-2 and Cancer.
Location: Department of Chemistry.
Collaborator: Assistant Professor Shiqing Xu.
Research Focus:
Developing selective inhibitors of Heme Oxygenase-1 (HO-1) for targeted cancer therapy.
Exploring novel inhibitors for the SARS-CoV-2 main protease.
Synthesizing and validating small molecule inhibitors.
Synthesizing and validating small molecule inhibitors.
Location: College of Medicine.
Collaborator: Distinguished Professor Vytas Bankaitis.
Research Focus:
Synthesizing and validating small molecule inhibitors targeting lipid signaling in the fungal pathogen Candida glabrata.
1. Resurrection of Recalled Pharmaceuticals
1. Resurrection of Recalled Pharmaceuticals
2. Novel Thiamin-based Bioactive Molecule Drug Delivery System
2. Novel Thiamin-based Bioactive Molecule Drug Delivery System
Location: Pharmaceutical Sciences.
Collaborator: Associate Professor of Hamed I. Ali.
Research Focus:
Developing innovative methods to eliminate toxic contaminants from recalled drugs, aiming to make these pharmaceuticals safe for reintroduction.
Creating a drug delivery system that improves pharmacodynamics and pharmacokinetics through the use of thiamin-based bioactive molecules.
Research Skills & Experience
Research Skills & Experience
Lab Equipment:
Proficient in operating advanced laboratory equipment, including the H-Cube Continuous-flow Hydrogenation Reactor for high-pressure hydrogen reduction of compounds.
Utilized the Monowave 300 Microwave Synthesis Reactor for high-temperature chemical reactions.
Applied the Ozone Engineering LG-7 Corona Discharge ozone generator for oxidation reactions.
Experienced with the Rayonet photoreactor, specializing in the photodeprotection of nitrobenzyl-caged compounds.
Chromatographic Techniques:
Extensive experience in various chromatographic methods, including Silica-gel, ion exchange, affinity, and HPLC, utilizing Agilent 1200 & 1100 Series HPLC systems.
Proficient in Flash Chromatography systems, such as CombiFlash, for organic purification and characterization.
Mass Spectrometry and Spectrophotometry:
Skilled in LC/MS, specifically microtof QII mass spectroscopy (Bruker), for the characterization of enzymatic products.
Utilized NMR (Varian & Bruker), IR, GC/MS, Cary 300 UV-Vis spectrophotometer, Cary Eclipse Fluorescence spectrophotometer, UV-Vis-NIR spectra & Fluorescent spectra measurements on a JASCO spectrometer.
Electrochemical Analysis: Proficient in Cyclic Voltammetry using the Epsilon E2 Electrochemical Analyzer.
Characterization and Purification: Expertise in the characterization and purification of enzymatic intermediates, substrates, and small molecules, employing a full scope of instrumentation, including NMR, HPLC, and LC/MS. Proficient in protein overexpression and purification.
Organic Synthesis:
Accomplished in total synthesis using modern techniques, including ozonolysis, photoreactor, hydrogenation, microwave, and a variety of chromatographic purification methods.
Executed multi-step organic synthesis with creativity to overcome synthetic chemistry challenges.
Production and Purification: Successfully produced and purified multi-gram to milligram quantities of light and air-sensitive synthetic compounds.
Molecular Design: Proven capability in the synthesis and design of various organic compounds, particularly those acting as molecular wires.
Problem Solving: Demonstrated ability to solve problems efficiently and in a timely fashion.
Training and Supervision: Adept at training and supervising new graduate and undergraduate students.
Communication: Strong communication skills facilitating effective collaboration and knowledge transfer within the laboratory setting.
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